在区域淀粉样蛋白和tau蛋白沉积和GMV比率之间的ALPS指数中介分析中，总效应在所有脑区均显著，但ALPS 指数仅在顶叶和颞叶中显示出中介效应（Pm=13.71%-17.86%）。

总的来说，这是一项探索性的研究，首次在人类中探讨了类淋巴系统功能在淀粉样蛋白和tau蛋白的沉积与认知功能障碍之间的作用，研究结果显示出ALPS 指数在淀粉样蛋白和 tau蛋白沉积与认知功能障碍之间起到重要中介效应，这再一次表明类淋巴系统功能障碍在AD的发病中起到一定的作用。同时，ALPS指数还可作为AD患者疾病进展或治疗评估的生物标志物。

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