JECCR:中山大学团队发现幽门螺旋杆菌诱导胃癌发生的新机制!

  • 2023-03-04 00:00
  • 来源:医药资讯网
  • 阅读:191

综上所述,这项研究阐明了ac4C及其乙酰转移酶NAT10在胃癌中的作用,揭示了一种幽门螺旋杆菌促进胃癌发生的新机制,为幽门螺旋杆菌感染所导致的胃癌提供了一种新的治疗思路。

参考文献:

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[3] Deng M, Zhang L, Zheng W, etal. Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. J Exp Clin Cancer Res. 2023 Jan 6;42(1):9. doi: 10.1186/s13046-022-02586-w.

[4] He L, Li H, Wu A, etal. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019 Dec 4;18(1):176. doi: 10.1186/s12943-019-1109-9.

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[6] Ito S, Horikawa S, Suzuki T, etal. Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA). J Biol Chem. 2014 Dec 26;289(52):35724-30. doi: 10.1074/jbc.C114.602698.

[7]Wei J, Nagy TA, Vilgelm A, et al. Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology. 2010 Oct;139(4):1333-43. doi: 10.1053/j.gastro.2010.06.018.


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